In fermentation, sampling is still the main information source about the status and chemical composition of the content of the fermenter,
therefore samples should be representative to the process. To minimize variability autosamplers are frequently used instead of manual sampling
but the characteristics of the autosamplers have to be explored for reliable operation. In addition, autosamplers can be coupled to process
analysers when the operation has to be systematically tested to ensure high-quality data from the samples.
The aim of this work is to test our autosampler-HPLC system in a systematically-designed way for complete exploration of its capabilities and
Goal is to
- maximise filtrate volume during sampling by fine-tuning the filtration module of the autosampler
- characterize the dilution module to compensate for systematic error.
What we offer
- Working with state-of-the-art equipment and processes
- Learning to design and analyse multifactorial experiments by the rules of Design of Experiments (DoE)
- Get an insight of the complexity of fermentations and their control with IT systems
- Learning the basics of HPLC measurements
- Acquire the skills of critical, problem-oriented thinking
The ideal candidate
- Motivated to generate high-quality data for an excellent thesis
- Has a deep desire to understand interrelations within systems with interconnected instruments
- Interested in fermentation monitoring and control (PAT)
- Has good English language skills
Time-frame and salary
This work will be done at TU WIEN, Research Area of Biochemical Engineering and can be started anytime. It is scheduled for 6 months and compensated with 300 € per month.